很多抗癌药物对消化道粘膜有损害作用,尤其抗代谢药,口腔粘膜反应常是最初表现的毒性反应。据文献报导,颈部以下癌症病人进行化疗而发生口腔合并症成人为39％,儿童为90％。包括口腔粘膜炎和潜在性感染。较常出现口腔炎的药物有氨甲喋呤、氟脲 Many anti-cancer drugs have a damaging effect on the digestive tract mucosa, especially antimetabolites, and oral mucosal reactions are often the initial manifestations of toxicity. According to reports in the literature, 39% of adults with oral complications undergo chemotherapy for cancer below the neck and 90% of children. Including oral mucositis and latent infection. The drugs that often appear stomatitis are methotrexate and fluorourea.