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[目的]研究益气活血祛湿膏对实验性糖尿病大鼠皮肤溃疡模型创面愈合率及病理组织学的影响。[方法]链脲佐菌素腹腔注射造成大鼠糖尿病模型,于背部切除1cm×1cm全层皮肤损伤造成皮肤溃疡模型,随机分为模型组、模型基质组、给药组。敷药2次/d,连续7d,用图象分析软件计算创面愈合率,羟脯氨酸试剂盒测定创面肉芽组织中羟脯氨酸含量,创面皮肤HE染色光镜观察病理变化。[结果]给药组创面愈合率、创面肉芽组织Hyp含量均优于模型组、模型基质组。给药组肉芽组织生长旺盛,成纤维细胞、毛细血管丰富,炎症细胞较少。[结论]益气活血祛湿膏具有促进大鼠糖尿病皮肤溃疡创面愈合的作用,其基质和中药组分对大鼠糖尿病皮肤溃疡创面的愈合均有一定的促进作用。
[Objective] To investigate the effect of Yiqi Huoxue Reliever cream on the wound healing rate and histopathology of skin ulcer model in experimental diabetic rats. [Method] Streptozotocin was intraperitoneally injected into the model of diabetic rats, and the model of skin ulcer caused by 1cm × 1cm full thickness skin injury was excised on the back. The models were randomly divided into model group, model matrix group and administration group. Dressing 2 times / d, continuous 7d, using image analysis software to calculate the rate of wound healing, hydroxyproline kit hydroxyproline content in wound granulation tissue, the wound surface of the HE staining light microscopy pathological changes. [Result] The wound healing rate and the content of Hyp in the wound granulation tissue in the treated group were better than those in the model group and model group. The granulation tissue of the administration group grew vigorously, the fibroblasts were rich in capillaries and the inflammatory cells were less. [Conclusion] Yiqi Huoxue Qushi Decoction can promote the wound healing of diabetic skin ulcer, and its matrix and Chinese medicine components can promote the healing of diabetic skin ulcer wounds in rats.