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从人的原发性结肠癌发现有类固醇激素,包括雌激素(E_2)、孕酮(Prog)、去氧睾丸酮(DHT)和类皮质糖(DEX)受体的存在。33例中有10例含有E_2受体,其中23例同时测四种受体,有6例含有3个受体(DHT、Prog、E_2)。所有70%的肿瘤含有1个或更多的受体。22例中有5例DEX受体阳性。文中引证很多作者的试验结果进行讨论,结肠癌与乳腺癌虽然是两个部位的癌瘤,但饮食性质可能是一个共同的因素,饮食中脂肪影响激素的产生,高脂肪和动物蛋白食物可增加大便及胆汁中的类固醇,肠道细菌能从胆汁产物产生类固醇雌激素。另外结肠癌也可能是激素依赖的癌瘤。
Steroid hormones, including the presence of estrogen (E2), progesterone (Prog), deoxytestosterone (DHT), and corticosteroid (DEX) receptors, are found in human primary colon cancer. Of the 33 cases, 10 contained E2 receptors, 23 of which measured four receptors simultaneously, and 6 of them contained 3 receptors (DHT, Prog, E2). All 70% of tumors contain 1 or more receptors. Five of 22 patients were positive for DEX receptors. Many authors’ experimental results are cited for discussion. Although colon cancer and breast cancer are two sites of cancer, dietary characteristics may be a common factor. Dietary fat affects hormone production, and high fat and animal protein foods may increase. In stool and steroids in bile, intestinal bacteria can produce steroid estrogens from bile products. In addition, colon cancer may also be a hormone-dependent cancer.