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用封闭群大耳白家兔16只,随机分为对照组和发热组。对照组测量动物的基础体温,不注射内毒素(ET),发热组动物I.V.ET后80min体温明显升高。给ET后80min处死动物。动物发热时丘脑下部组织AC和PDE的活性均增强,与对照组动物比较差异均非常显著(P<0.001),发热组动物脑干AC活性虽有增强趋势但统计学意义,发热组动物脑皮质AC活性减弱与对照组动物比较差异非常显著(P<0.01),作者推论:家兔ET性发热是由于丘脑下部AC活性增强使cAMP产生增加所致。
Sixteen closed white rabbits were randomly divided into control and fever groups. The basal body temperature of animals in the control group was measured, and endotoxin (ET) was not injected. The body temperature of the animals in the fever group was significantly increased at 80 minutes after I.V.ET. Animals were sacrificed 80 min after ET. The activities of AC and PDE in the hypothalamus were increased in animals with fever and were significantly different from those in the control animals (P<0.001). Although the AC activity in the brainstem of the animals in the fever group had an increasing trend, the statistical significance was found in the animals. The decrease in AC activity was significantly different from that in the control animals (P<0.01). The authors conclude that ET fever in rabbits is due to increased cAMP production due to enhanced AC activity in the hypothalamus.