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本文将5％硫酸新霉素液0.1ml以一次给药方式引入豚鼠听泡,采用全耳蜗铺片术,借助相差显微镜研究耳蜗组织学改变。结论为:(1) 中耳局部应用新霉素可导致内耳柯替氏器损害,且随动物存活时间的延长而加重;(2) 外毛细胞对毒性较敏感,损害严重,内毛细胞正常;(3) 损害部位主要在第2、3回;(4) 与其它文献报道相比,中耳局部应用耳毒性抗生素引起的耳毒性反应较全身应用时迅速。并针对此四点进行了讨论。
In this paper, 0.1 ml of 5% neomycin sulfate solution was introduced into guinea pigs for one time administration, and cochlear histological changes were observed by phase-contrast microscopy. Conclusion: (1) Neomycin topical application of neomycin can cause damage to the inner ear of Kreutzeria, and aggravated with the extension of the survival time of the animals; (2) Outer hair cells are more sensitive to toxicity, severe damage, normal hair cells ; (3) the lesion is mainly in the second and third back; (4) compared with other reports, ototoxicity induced by ototoxic antibiotics in the middle ear was faster than systemic application. And for the four points were discussed.