论文部分内容阅读
目的:探讨人类免疫缺陷病毒(HIV)合并乙型肝炎病毒(HBV)感染对患者的免疫功能和肝功能的影响。方法:选取广州市第八人民医院2009年4月至2015年4月收治的已确诊Hl V阳性感染者266例,其中包括单纯HIV感染者220例,合并HBV感染者46例,选取同时期单纯HBV感染者50例,抽取血样比较分析3组患者CD4~+、CD8~+T淋巴细胞数,并进行肝功能检测,比较3组患者丙氨酸氨基转移酶(ALT)、天冬氨酸转移酶(AST)、总胆红素(TBIL)数值。结果:HIV合并HBV感染者CD8~+T淋巴细胞数明显高于单纯HIV感染者以及单纯HBV感染者,差异具有统计学意义(P<0.05),合并感染患者外周血CD4~+T淋巴细胞计数与单纯HIV患者比较,差异无统计学意义(P>0.05),两组均低于单纯HBV感染患者,差异具有统计学意义(P<0.05)。肝功能检测,合并组ALT、AST高于单纯HIV组,但低于单纯HBV组,差异具有统计学意义(P<0.05),3组TBIL比较,差异无统计学意义(P>0.05)。结论:HIV感染合并HBV感染能够增加机体的免疫应答,增加对机体的损害,同时也增加对肝脏的损害。
Objective: To investigate the effect of human immunodeficiency virus (HIV) combined with hepatitis B virus (HBV) infection on immune function and liver function in patients. Methods: Two hundred and sixty-six Hl V-positive patients admitted from April 2009 to April 2015 in Guangzhou Eighth People’s Hospital were selected, including 220 HIV-infected patients and 46 HBV infected patients. 50 patients with HBV infection were enrolled in this study. Blood samples were collected for analysis of CD4 ~ +, CD8 ~ + T lymphocyte counts and liver function in three groups. The levels of alanine aminotransferase (ALT), aspartate Enzyme (AST), total bilirubin (TBIL) values. Results: The number of CD8 ~ + T lymphocytes in HIV-infected patients was significantly higher than that in HIV-infected patients and HBV-infected patients (P <0.05). The CD4 ~ + T lymphocyte count There was no significant difference between the two groups (P> 0.05), but the difference was statistically significant (P <0.05). The liver function tests showed that ALT and AST in the combined group were higher than those in the simple HIV group but lower than those in the pure HBV group (P <0.05). There was no significant difference in TBIL between the three groups (P> 0.05). Conclusion: HIV infection combined with HBV infection can increase the body’s immune response, increase the damage to the body, but also increase the damage to the liver.