Age-at-injury effects of microglial activation following traumatic brain injury:implications for tre

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Traumatic brain injury (TBI) remains one of the leading caus-es of disability and death in infants and children. Studies have demonstrated that the youngest age group (especially≤4 years old) exhibit worse functional outcome following moderate to severe TBI compared to older children or adults (Anderson et al., 2005;Emami et al., 2017).These data suggest that age-at-in-jury may be an important determinant of outcome, as damage to the developing brain at a young age likely disrupts normal brain development which will influence cognitive and psycho-social skills.
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