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目的:观察38度稻花香白酒对大鼠的亚急性毒性作用。方法:体质量相当的Wister大鼠随机分为高、中、低剂量组和对照组,每组15只,雌8雄7,高剂量组3.44mL/kg,中剂量组1.72mL/kg,低剂量组0.86mL/kg。,每日早上9:00各实验大鼠经口给药1次(对照组给予蒸馏水1.72mL/kg),连续45d。每周测体质量,末次给药后取血测定血常规,肝功能,测定各脏器系数,做心、肝、脾、肺,肾病理检查。结果:38度稻花香白酒各组大鼠血常规,肝功能各项指标差异无显著意义。体质量变化雌雄之间差异有显著意义。病理检查发现,心脏、肺脏、脾脏和肾脏等脏器均无异常变化。对肝脏有损坏作用,其肝脏的病变严重程度与剂量相关。结论:38度稻花香白酒对大鼠肝脏有亚急性毒性作用。
Objective: To observe the subacute toxic effect of 38% rice huaxiang liquor on rats. Methods: Wister rats with similar body weight were randomly divided into high, medium and low dose groups and control group, with 15 rats in each group, 8 male and 7 female, 3.44 mL / kg in high dose and 1.72 mL / kg in middle dose Dose group 0.86mL / kg. , Every morning 9:00 each experimental rats were administered orally (control group given distilled water 1.72mL / kg), continuous 45d. Weekly body mass measurement, blood test after the last administration of blood, liver function, determination of various organ coefficients, heart, liver, spleen, lung, kidney pathological examination. Results: There was no significant difference in the indexes of blood and liver function among 38 degrees Daohuaxiang liquor group rats. Body weight changes between male and female have significant differences. Pathological examination found no abnormal changes in heart, lung, spleen and kidney and other organs. Damage to the liver, the severity of the lesion in the liver is dose-related. Conclusion: 38 degrees rice wine Huaxiang liquor on rat liver subacute toxicity.