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药物对胶原病疗效较好的是系统性红斑性狼疮(简称SLE)、皮肌炎、多发性肌炎和抗DNA(能抽出的核抗原)抗体价高的混合型胶原病。疗效差的是硬皮病。一、SLE的治疗:主要是皮质类固醇药物,以强的松、强的松龙为好。地塞米松、倍他米松、Medrol等的抗炎作用较强的松、强的松龙大数倍,其蛋白分解作用更强。强的松的剂量为1毫克/公斤/日,用至患者血清γ-球蛋白正常、自家抗体消失或降低后改用每日10毫克维持。这样的剂量引起医原性疾病较少,导致急性恶化的频率也较少。皮质类固醇的减量:20毫克/日以上时应每隔三日减
Drugs on the collagen disease is better than the systemic lupus erythematosus (SLE), dermatomyositis, polymyositis and anti-DNA (nuclear antigen can be extracted) antibody high price of mixed collagen disease. Poor efficacy of scleroderma. First, the treatment of SLE: The main corticosteroid drugs to prednisone, prednisolone as well. Dexamethasone, betamethasone, Medrol and other anti-inflammatory effect of pine, predominate large number, its protein decomposition stronger. Prednisone at a dose of 1 mg / kg / day, until the patient’s serum γ-globulin normal, disappear or reduce their own antibodies to 10 mg daily maintenance. Such a dose causes less iatrogenic disease, resulting in less frequent acute exacerbations. Corticosteroid reduction: 20 mg / day or more should be reduced every three days