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已证实胞外Ｃａ2 + 可通过激活甲状旁腺主细胞的钙敏感受体 (ＣａＲ)来调节甲状旁腺激素 (ＰＴＨ)的释放[1 ] 。在继发性甲状旁腺功能亢进 (ＳＨＰＴ)患者 ,血ＰＴＨ常明显增高 ,与血Ｃａ2 + 变化不平行。本研究旨在探讨ＣａＲ是否在ＳＨＰＴ的发病过程中起重要作用。一、材料?
Extracellular Ca2 + has been shown to regulate the release of parathyroid hormone (PTH) by activating the calcium-sensitive receptor (CaR) in the primary parathyroid cells [1]. In patients with secondary hyperparathyroidism (SHPT), blood PTH often increased significantly, with changes in blood Ca2 + is not parallel. This study aimed to investigate whether CaR plays an important role in the pathogenesis of SHPT. First, the material?