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【摘要】 目的:探討高频振荡通气联合肺表面活性物质救治早产儿呼吸窘迫综合征的效果。方法:选取2014年5月-2017年5月期间本院新生儿科收治的90例早产儿呼吸窘迫综合征患儿,采用随机数字表法将所有患儿分为观察组和对照组,每组各45例,对照组采用常频机械通气联合肺表面活性物质治疗,观察组采用高频振荡通气联合肺表面活性物质治疗,观察两组患儿治疗前后肺氧合功能、血气分析变化及平均住院时间、上机时间、治愈率。结果:两组患儿治疗后肺氧合功能及血气分析指标均较治疗前有显著改善,且治疗后观察组肺氧合功能及血气分析指标明显优于对照组,差异均有统计学意义(P<0.05);观察组患儿的平均住院时间及上机时间均显著短于对照组,观察组患儿治愈率为93.33%,显著高于对照组75.56%,差异均有统计学意义(P<0.05)。结论:高频振荡通气联合肺表面活性物质救治早产儿RDS效果较常频通气效果显著,且改善血气和肺氧合功能较良好,临床应用前景广阔。
【关键词】 高频振荡通气; 常频机械通气; 肺表面活性物质; 早产儿呼吸窘迫综合征
【Abstract】 Objective:To investigate the efficacy of high frequency oscillatory ventilation combined with pulmonary surfactant in the treatment of respiratory distress syndrome in premature infants.Method:Fifty preterm children with respiratory distress syndrome admitted in our hospital from May 2014 to May 2017 were enrolled in this study,according to random number table method,all children were divided into observation group and control group,45 cases in each group.The control group was treated with conventional mechanical ventilation combined with pulmonary surfactant treatment,the observation group was treated with high frequency oscillation ventilation combined with pulmonary surfactant.Before and after treatment,the pulmonary oxygenation function,changes of pulmonary oxygenation function,blood gas analysis and the average hospitalization time,operation time and cure rate of two groups were observed.Result:After treatment,the pulmonary function and blood gas analysis index of the two groups were significantly improved than before treatment,and the observation group of those were significantly better than the control group,the differences were statistically significant(P<0.05).The average hospitalization time and the duration of mechanical ventilation of observation group were significantly shorter than those of the control group,the observation group cure rate was 93.33%,significantly higher than 75.56% in the control group,the differences were statistically significant(P<0.05).Conclusion:High frequency oscillatory ventilation combined with pulmonary surfactant treatment of premature infants with respiratory distress syndrome is more effective than regular frequency ventilation,improves blood gas and oxygenation function of lung,and has a bright future in clinical application.
【Key words】 High frequency oscillatory ventilation; Frequent frequency mechanical ventilation; Pulmonary surfactant; Premature infant respiratory distress syndrome
First-author’s address:Shantou Chaonan Minsheng Hospital,Shantou 515144,China [9]骆娟,蒋虹,李茂军,等.肺表面活性物质预防早产儿呼吸窘迫综合征的疗效评价[J].实用医院临床杂志,2014,11(2):77-79.
[10]宋姗.不同频率机械通气方式治疗早产儿呼吸窘迫综合征的疗效观察[J].临床肺科杂志,2017,22(6):1134-1136.
[11]林逾峰.早产儿呼吸窘迫综合征无创正压通气联合肺表面活性物质救治的临床研究[J].中国妇幼保健,2014,29(13):2124-2126.
[12]周英,顾美群,李明霞,等.常频与高频呼吸机治疗早产儿呼吸窘迫综合征疗效对比[J].中国新生儿科杂志,2016,31(1):19-23.
[13]邹雅,黄惜华,游楚明,等.不同机械通气模式对早产儿呼吸窘迫综合征血流动力学的影响及护理[J].临床护理杂志,2016,15(5):33-35.
[14]田丽.无创呼吸机联合咖啡因治疗极低出生体重早产儿呼吸窘迫综合征的临床研究[J].中国医学创新,2017,14(3):63-66.
[15]刘红霞,力小玲,刘仁红,等.肺表面活性物质治疗早产儿呼吸窘迫综合征临床疗效分析[J].海南医学,2012,24(23):46-48.
[16]新春,梅花,刘春枝,等.肺表面活性物质蛋白B、C基因变异与蒙古族早产儿呼吸窘迫综合征相关性研究[J].临床儿科杂志,2016,34(9):645-650.
[17]潭开卷,陈雄,黄晓凌.高频震荡通气治疗重症新生儿呼吸窘迫综合征的临床分析[J].基层医学论坛,2013,17(13):1642-1644.
[18]张俊,朱绪亮,郭军,等.机械通气联合肺表面活性物质治疗早产儿呼吸窘迫综合征的临床分析[J].南昌大学学报(医学版),2013,53(5): 36-39.
[19]鄧云森,李盛强,徐晓清,等.高频振荡通气在新生儿呼吸窘迫综合征治疗中的作用[J].实用医技杂志,2017,24(1):82-83.
[20]雷克竞,谭静,唐国红,等.高频振荡通气治疗新生儿呼吸窘迫综合征的疗效观察[J].西部医学,2016,28(5):705-708.
[21]李小燕,王慧琴,柴竹青,等.机械通气治疗新生儿呼吸窘迫综合征疗效观察[J].安徽医药,2016,20(5):934-936.
[22]高翔羽,杨波,黑明燕,等.三种无创正压通气在早产儿呼吸窘迫综合征初始治疗中应用的随机对照研究[J].中华儿科杂志,2014,52(1):34-40.
【关键词】 高频振荡通气; 常频机械通气; 肺表面活性物质; 早产儿呼吸窘迫综合征
【Abstract】 Objective:To investigate the efficacy of high frequency oscillatory ventilation combined with pulmonary surfactant in the treatment of respiratory distress syndrome in premature infants.Method:Fifty preterm children with respiratory distress syndrome admitted in our hospital from May 2014 to May 2017 were enrolled in this study,according to random number table method,all children were divided into observation group and control group,45 cases in each group.The control group was treated with conventional mechanical ventilation combined with pulmonary surfactant treatment,the observation group was treated with high frequency oscillation ventilation combined with pulmonary surfactant.Before and after treatment,the pulmonary oxygenation function,changes of pulmonary oxygenation function,blood gas analysis and the average hospitalization time,operation time and cure rate of two groups were observed.Result:After treatment,the pulmonary function and blood gas analysis index of the two groups were significantly improved than before treatment,and the observation group of those were significantly better than the control group,the differences were statistically significant(P<0.05).The average hospitalization time and the duration of mechanical ventilation of observation group were significantly shorter than those of the control group,the observation group cure rate was 93.33%,significantly higher than 75.56% in the control group,the differences were statistically significant(P<0.05).Conclusion:High frequency oscillatory ventilation combined with pulmonary surfactant treatment of premature infants with respiratory distress syndrome is more effective than regular frequency ventilation,improves blood gas and oxygenation function of lung,and has a bright future in clinical application.
【Key words】 High frequency oscillatory ventilation; Frequent frequency mechanical ventilation; Pulmonary surfactant; Premature infant respiratory distress syndrome
First-author’s address:Shantou Chaonan Minsheng Hospital,Shantou 515144,China [9]骆娟,蒋虹,李茂军,等.肺表面活性物质预防早产儿呼吸窘迫综合征的疗效评价[J].实用医院临床杂志,2014,11(2):77-79.
[10]宋姗.不同频率机械通气方式治疗早产儿呼吸窘迫综合征的疗效观察[J].临床肺科杂志,2017,22(6):1134-1136.
[11]林逾峰.早产儿呼吸窘迫综合征无创正压通气联合肺表面活性物质救治的临床研究[J].中国妇幼保健,2014,29(13):2124-2126.
[12]周英,顾美群,李明霞,等.常频与高频呼吸机治疗早产儿呼吸窘迫综合征疗效对比[J].中国新生儿科杂志,2016,31(1):19-23.
[13]邹雅,黄惜华,游楚明,等.不同机械通气模式对早产儿呼吸窘迫综合征血流动力学的影响及护理[J].临床护理杂志,2016,15(5):33-35.
[14]田丽.无创呼吸机联合咖啡因治疗极低出生体重早产儿呼吸窘迫综合征的临床研究[J].中国医学创新,2017,14(3):63-66.
[15]刘红霞,力小玲,刘仁红,等.肺表面活性物质治疗早产儿呼吸窘迫综合征临床疗效分析[J].海南医学,2012,24(23):46-48.
[16]新春,梅花,刘春枝,等.肺表面活性物质蛋白B、C基因变异与蒙古族早产儿呼吸窘迫综合征相关性研究[J].临床儿科杂志,2016,34(9):645-650.
[17]潭开卷,陈雄,黄晓凌.高频震荡通气治疗重症新生儿呼吸窘迫综合征的临床分析[J].基层医学论坛,2013,17(13):1642-1644.
[18]张俊,朱绪亮,郭军,等.机械通气联合肺表面活性物质治疗早产儿呼吸窘迫综合征的临床分析[J].南昌大学学报(医学版),2013,53(5): 36-39.
[19]鄧云森,李盛强,徐晓清,等.高频振荡通气在新生儿呼吸窘迫综合征治疗中的作用[J].实用医技杂志,2017,24(1):82-83.
[20]雷克竞,谭静,唐国红,等.高频振荡通气治疗新生儿呼吸窘迫综合征的疗效观察[J].西部医学,2016,28(5):705-708.
[21]李小燕,王慧琴,柴竹青,等.机械通气治疗新生儿呼吸窘迫综合征疗效观察[J].安徽医药,2016,20(5):934-936.
[22]高翔羽,杨波,黑明燕,等.三种无创正压通气在早产儿呼吸窘迫综合征初始治疗中应用的随机对照研究[J].中华儿科杂志,2014,52(1):34-40.