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目的 :探讨性激素和内皮素 (ET)在前列腺增生发病过程中的相互关系。 方法 :采用给狗皮下埋置性缴素缓释硅胶囊的方法使狗前列腺产生增生样病理改变 (给药组 )。用RIA方法检测正常组、老年组和给药组狗前列腺组织中的ET的含量。 结果 :给药组产生与老年组类似的前列腺增生样病理改变 ,但和正常组相比 ,老年组前列腺组织中ET含量明显升高 (P <0 0 5 ) ,而与给药组无显著差异 (P >0 0 5 )。 结论 :性激素平衡失调能导致前列腺产生增生样病理改变。ET在前列腺增生发病过程中可能起一定的作用 ,但ET含量的升高与性激素没有明显的直接联系。
Objective: To explore the relationship between sex hormones and endothelin (ET) in the pathogenesis of benign prostatic hyperplasia. Methods: The method of giving the subcutaneous implantable sustained-release silicone capsule to the dog resulted in the pathological changes of the prostatic hyperplasia (administration group). The content of ET in dog’s prostatic tissue of normal group, old group and administration group was detected by RIA method. Results: Compared with the normal group, the content of ET in the prostatic tissue was significantly increased in the drug-treated group (P <0.05), but no significant difference was found between the drug-treated group and the drug-treated group (P> 0 0 5). Conclusion: Hormone imbalance can lead to prostate hyperplasia-like pathological changes. ET may play a role in the pathogenesis of benign prostatic hyperplasia, but there is no obvious direct relationship between ET and sex hormone.