A sensitive electroanalytical method for quantification of pheniramine in pharmaceutical formulation has been investigated on the basis of the enhanced electrochemical response at glassy carbon electrode modified with multi-walled carbon nanotubes in the presence of sodium lauryl sulfate. The experimental results suggest that the pheniramine in anionic surfactant solution exhibits electrocatalytic effect resulting in a marked enhancement of the peak current response. Peak current response is linearly dependent on the concentration of pheniramine in the range 2001500 mg/mL with correlation coefficient 0.9987. The limit of detection is 58.31 mg/mL. The modified electrode shows good sensitivity and repeatability. A sensitive electroanalytical method for quantification of pheniramine in pharmaceutical formulation has been investigated on the basis of the enhanced electrochemical response at glassy carbon electrode modified with multi-walled carbon nanotubes in the presence of sodium lauryl sulfate. The experimental results suggest that the pheniramine in anionic peak current response is linearly dependent on the concentration of pheniramine in the range 2001500 mg / mL with correlation coefficient 0.9987. The limit of detection is 58.31 mg / mL. The modified electrode shows good sensitivity and repeatability.