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实验观察了“安全”减压和不适当减压条件下家兔减压病(DCS)的发病情况、Doppler超声以及血浆中TxB_2和6-keto-PGF_(1a)的变化;还观察了消炎痛对DCS的预防怍用。结果显示:减压愈不当,DCS发病愈重,Doppler超声气泡探测仪检测到的级别愈高。血浆TxB_2、6-keto-PGF_(1α)值在濒死动物中明显升高(P<0.01);存活动物中,TxB_2经历了下降、再恢复的过程(P<0.01),而6-keto-PGF_(1α)值未见明显变化。消炎痛在抑制血浆TxB_2升高的同时,有效地降低了DCS发病率。此结果表明:TxA_2、PGI_2参与了重型DCS的发病过程,消炎痛的顶防作用与抑制花生四烯酸代谢物的生成有关。
The incidences of decompression sickness (DCS), Doppler ultrasound and the changes of TxB_2 and 6-keto-PGF_ (1a) in rabbits under “safe” decompression and inappropriate decompression were observed. Indomethacin DCS use prevention. The results showed that: the more improper decompression, DCS more serious, Doppler ultrasonic bubble detector detected the higher the level. The TxB_2, 6-keto-PGF_ (1α) levels in plasma were significantly increased in dying animals (P <0.01), while those in surviving animals decreased and then recovered (P <0.01) PGF_ (1α) values showed no significant change. Indomethacin effectively reduces the incidence of DCS while inhibiting the increase of plasma TxB_2. The results showed that: TxA_2, PGI_2 involved in the pathogenesis of heavy DCS, the top-anti-inflammatory effect of indomethacin and inhibit the production of arachidonic acid metabolites.