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ｐ2 7和 ｐ1 6于 1 994年被克隆成功。属于细胞周期蛋白依赖激酶抑制剂的两个不同家族。经研究证明二者都是抑癌基因。均通过结合并抑制细胞周期蛋白依赖激酶 ,从而抑制细胞从Ｇ1 期到Ｓ期的转化[1 ,6 ] 。因此它们表达水平的变化可能与肺癌的发生发展机制及癌的预后相关。我们
p2 7 and p1 6 were successfully cloned in 1994. Belong to two different families of cyclin-dependent kinase inhibitors. The study proved that both are tumor suppressor genes. All through the combination and inhibition of cyclin-dependent kinase, thereby inhibiting cells from G1 phase to S phase transformation [1, 6]. Therefore, the changes of their expression levels may be related to the occurrence and development of lung cancer and the prognosis of cancer. we