论文部分内容阅读
近年来经基础和临床的研究表明;烟酰胺能改善房室传导,增强窦房结的功能,预防实验性心律失常的发生,提高常咯林抗心律失常的治疗指数,对Ⅰ～Ⅲ°房室传导阻滞、病态窦房结综合征等病人疗效较好。毒副作用小。兹简述如下: 一、抗心律失常药理研究 (一)改善房室传导,增强窦房结的功能:张克绵等用含硫酸锰的洛氏液灌流离体兔心,出现心律减慢,P—R间期延长,进而出现Ⅱ～Ⅲ°房室传导阻滞,烟酰胺20～40mg能使心律自78±31.3次/min增至125.5±9.2次/min(P<
In recent years, basic and clinical studies have shown that nicotinamide can improve atrioventricular conduction and enhance the function of the sinus node to prevent the occurrence of experimental arrhythmia and improve the treatment index of anti-arrhythmia of behulin. Room conduction block, sick sinus syndrome and other patients better effect. Toxic side effects. Is briefly described as follows: First, the anti-arrhythmic pharmacological studies (a) to improve atrioventricular conduction and enhance the function of the sinus node: Zhang Mian and other containing manganese sulfate in vitro perfusion of rabbit heart, a slow heart rate, P- R interval prolonged, resulting in Ⅱ ~ Ⅲ ° atrioventricular block, niacinamide 20 ~ 40mg can make the heart rate from 78 ± 31.3 times / min to 125.5 ± 9.2 times / min (P <