1例38岁女性精神分裂症病人,因严重攻击行为而于1991年7月就诊。经 zu-clopenthixol、泰尔登、氯丙嗪和卡马西平治疗无效,而于9月换用氯氮平。治疗前,白细胞计数及其分类正常。5w 后,白细胞计数增至11.7×10~9/l,嗜酸性细胞为0.7×10~9/l,1w 后,白细胞计数13.9×10~9/l,嗜酸性细胞增至1.4×10~9/l;又1w 后,嗜酸性细胞增至1.5×10~9/l,氯氮平被停用。4d 后,白 A 38-year-old woman with schizophrenia attended a clinic in July 1991 for serious attacks. The zu-clopenthixol, telfon, chlorpromazine and carbamazepine treatment ineffective, and in September for clozapine. Before treatment, white blood cell count and its classification were normal. After 5 weeks, the white blood cell count increased to 11.7 × 10 ~ 9 / l and the eosinophil count was 0.7 × 10 ~ 9 / l. After 1 w, the white blood cell count was 13.9 × 10 ~ 9 / l and the eosinophil increased to 1.4 × 10 ~ 9 / l; After 1w, eosinophils increased to 1.5 × 10 ~ 9 / l, clozapine was discontinued. After 4d, white