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动脉粥样硬化是一种脂质诱导的慢性血管壁炎症反应,是血管为应对血脂异常和血流动力学应激(涉及血管细胞激活、功能障碍以及白细胞浸润)而产生的一种病理现象.作为一类细胞周期和细胞凋亡中的重要调控分子,长链非编码RNAs(Long noncoding RNAs,lncRNAs)在表观遗传调控、转录调控和转录后调控等多个阶段干扰基因表达或信号通路.越来越多的研究表明,lncRNAs在内皮细胞、血管平滑肌细胞、巨噬细胞及其相关细胞因子构成的复杂网络中通过调控血管壁功能、脂质代谢和免疫反应,影响动脉粥样硬化进程.本文着重介绍lncRNAs在动脉粥样硬化血管功能调控中的作用机制.“,”Atherosclerosis is universally recognized as a chronic lipid-induced inflammation of the vessel wall in response to dyslipidemia and haemodynamic stress,which is involved in dysfunction and activation of resident vascular cells as well as infiltration of leukocytes.As an important regulatory molecule of cell cycle and apoptosis,the long noncoding RNAs (IncRNAs) interfere gene expression or signaling pathway in epigenetic regulation,transcription and post transcription regulation.Researches have shown that lncRNAs influence the process of atherosclerosis in endothelial cells,vascular smooth muscle cells,macrophages and complex network constituted of related cytokines through regulating vascular wall function,lipid metabolism and immune response.This article focuses on the role of lncRNAs in the regulation of vascular function in atherosclerosis.This article is supported by National Natural Science Foundation of China (81670338,91339101).