目的 :观察龟板对脊髓损伤后脊髓雌激素α受体 (ER -α)及其基因表达的影响。方法 :以改良的Allen法建立大鼠脊髓损伤模型 ,随机分为对照组、模型组和龟板治疗组 ,用免疫组织化学和原位杂交方法检测脊髓中ER -α及其mRNA的表达。结果 :模型组中脊髓ER -α受体及其mRNA的阳性细胞数与对照组比较显著减少 ;治疗组中ER -α及其mRNA的阳性细胞数与模型组比较显著增加。结论 :龟板可增加脊髓损伤后脊髓ER -α及其基因的表达。 Objective : To observe the effect of turtle shell on the expression of estrogen receptor α (ER-α) and its gene in spinal cord after spinal cord injury. METHODS: Rat spinal cord injury models were established by modified Allen method. They were randomly divided into control group, model group and turtle plate treatment group. The expression of ER-α and its mRNA in spinal cord was detected by immunohistochemistry and in situ hybridization. RESULTS: The number of positive cells in the spinal cord of ER-α receptor and its mRNA in the model group was significantly lower than that in the control group. The number of positive cells in the treatment group was significantly higher than that in the model group. Conclusion: Turtle plate can increase the expression of ER-α and its gene in spinal cord after spinal cord injury.