利什曼原虫可以感染人类巨噬细胞并引起一系列临床症状,但大多数皮肤和内脏感染者并无临床症状或有自限性,这主要是由于感染后的个体可以通过Th1细胞介导的长期免疫反应以防止再感染。已有研究结果提示,应用特定的重组的原虫抗原作为疫苗诱导的保护性T细胞免疫反应可能是更有效、更安全的选择。因此,鉴定出原虫感染时 Leishmania can infect human macrophages and cause a series of clinical symptoms, but most skin and visceral infections have no clinical symptoms or are self-limiting, mainly due to the fact that infected individuals can be mediated by Th1 cells Long-term immune response to prevent reinfection. It has been suggested that using a specific recombinant protozoal antigen as a vaccine-induced protective T cell immune response may be a more effective and safer option. Therefore, the protozoal infection was identified