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早期的实验研究证明,饲料中钙含量降低增加铅的肠道吸收率和铅的毒性。20世纪70年代初期,Mahaffey(1970,1973)报道,摄取低钙饲料(0.1％ Ca)的大鼠10周后的血铅水平比摄入相同数量铅(200 mg/L饮水)而饲料钙正常(0.7％ Ca)的大鼠高约4倍。其他研究者(Hsu F S,1975;Barton J C,1978;Quarlerman J,1978;Ziegler E E,1978;Johnson N E,1979)对不同种属动物(猪、羊、小鼠)所做的研究也发现,饲料钙含量与血铅水平呈负相关关系。
Early experimental studies demonstrated that reduced calcium in the diet increased intestinal absorption of lead and lead toxicity. In the early 1970s, Mahaffey (1970, 1973) reported that blood lead levels in rats taking low-calcium diets (0.1% Ca) ten weeks after drinking the same amount of lead (200 mg / L of drinking water) (0.7% Ca) of rats about 4 times higher. Studies by researchers (Hsu FS, 1975; Barton JC, 1978; Quarlerman J, 1978; Ziegler EE, 1978; Johnson NE, 1979) on different species of animals (pigs, sheep and mice) also found that feed Calcium content and blood lead levels were negatively correlated.