目的　评价利巴韦林葡萄糖注射液的安全性。方法　观察利巴韦林葡萄糖注射液对小鼠的急性毒性，对家兔红细胞的体外溶血作用，对兔耳血管的刺激性和对豚鼠的致敏作用。结果　小鼠灌胃和静脉注射利巴韦林的ＬＤ５０ 分别为６３０９６ ｍｇ／ｋｇ 和１３８０４ ｍｇ／ｋｇ 。未见明显致敏作用及血管刺激性。在６ 小时内，未见体外溶血和红细胞粘集反应。结论　利巴韦林葡萄糖注射液对实验动物无明显毒性反应。 Objective To evaluate the safety of ribavirin glucose injection. Methods The acute toxicity of ribavirin glucose injection to mice, in vitro hemolysis of rabbit erythrocytes, irritation of rabbit ear vessels and sensitization to guinea pigs were observed. Results The LD50 of ribavirin gavage and intravenous injection in mice was 63096 mg / kg and 13804 mg / kg, respectively. No obvious sensitization and vascular irritation. In 6 hours, no in vitro hemolysis and erythrocyte adhesion reaction. Conclusion Ribavirin glucose injection has no obvious toxicity to experimental animals.