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目的探讨尼美舒利分散片联合盐酸氟桂利嗪治疗偏头痛的临床疗效。方法选取2013年6月—2015年1月环江毛南族自治县人民医院收治的偏头痛患者60例,按治疗方法不同分为观察组与对照组,各30例。对照组患者予以盐酸氟桂利嗪治疗,观察组患者在对照组基础上加用尼美舒利分散片治疗。观察两组患者临床疗效、治疗前后视觉模拟评分法(VAS)评分、持续时间、复发情况及不良反应发生情况。结果观察组患者总有效率高于对照组,差异有统计学意义(P<0.05);治疗前两组患者VAS评分、持续时间比较,差异无统计学意义(P>0.05),治疗后观察组患者VAS评分低于对照组,持续时间短于对照组,差异有统计学意义(P<0.05);两组患者复发率、不良反应发生率比较,差异无统计学意义(P>0.05)。结论尼美舒利分散片联合盐酸氟桂利嗪治疗偏头痛的临床疗效显著,可改善患者头痛症状,缩短头痛持续时间。
Objective To investigate the clinical efficacy of nimesulide dispersible tablets combined with flunarizine hydrochloride in the treatment of migraine. Methods From June 2013 to January 2015, 60 migraineurs were treated in Huanjiang Maonan Autonomous County People’s Hospital. According to the different treatment methods, the patients were divided into observation group and control group, with 30 cases in each group. Patients in the control group were treated with flunarizine hydrochloride. Patients in the observation group were treated with nimesulide dispersible tablets on the basis of the control group. The clinical efficacy, visual analogue scale (VAS) score, duration, recurrence and adverse reactions before and after treatment were observed in both groups. Results The total effective rate of the observation group was higher than that of the control group (P <0.05). There was no significant difference in VAS score and duration between the two groups before treatment (P> 0.05) The VAS score of patients was lower than that of the control group, and the duration of VAS was shorter than that of the control group (P <0.05). There was no significant difference in the recurrence rate and incidence of adverse reactions between the two groups (P> 0.05). Conclusions Nimesulide dispersible tablets combined with Flunarizine Hydrochloride for the treatment of migraine have significant clinical effects, which can improve the symptoms of headache and shorten the duration of headache.