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目的:观察水蛭和虻虫不同剂量配伍对血瘀大鼠血液流变学的影响,探讨药对剂量配比的合理性。方法:将大鼠随机分为空白对照组、模型对照组和4个不同剂量比的水蛭、虻虫配伍组(水蛭∶虻虫分别为3∶4,4∶3,3∶1,6∶1,总剂量均为1 200 mg.kg-1)。连续给药7 d。于d 6给药1 h后,除空白对照组外,其余各组以皮下注射盐酸肾上腺素及冰水浴复制大鼠血瘀证模型。次晨给药后2 h采血,测定血液流变学指标。结果:不同配比的水蛭、虻虫药对均能明显改善大鼠血瘀模型的血液流变学异常,其中配伍2组(4∶3)、配伍3组(3∶1)对血细胞比容、红细胞聚集指数的作用较强。配伍3组(3∶1)对血浆黏度、卡松黏度的作用较强。配伍3组(3∶1)、配伍4组(6∶1)对血全黏度和全血还原黏度作用较强;配伍4组(6∶1)对红细胞变形指数作用较强。结论:在总剂量相同的条件下,水蛭剂量相对较大的配伍组(3∶1,6∶1)对血液流变学指标的作用较明显。
OBJECTIVE: To observe the effect of different doses of leech and pinworm on the hemorheology in blood stasis rats, and to explore the rationality of the dose ratio of the drugs. Methods: The rats were randomly divided into blank control group, model control group and 4 leeches with different dose ratios, the group of pinworm (leech: pinworm were 3: 4, 4: 3, , The total dose was 1 200 mg.kg-1). Continuous administration of 7 d. After d 6 administration for 1 h, except for the blank control group, the other groups were given subcutaneous injection of epinephrine hydrochloride and ice-water bath to duplicate the rat model of blood stasis. Second morning after administration of blood 2 h, determination of hemorheological parameters. Results: Hematopoietic parameters of blood stasis model were significantly improved by different ratios of leeches and scabies. The compatibility of 2 groups (4: 3) and 3 groups (3: 1) , The role of erythrocyte aggregation index stronger. Compatibility 3 groups (3: 1) on the plasma viscosity, card pine stronger role. Compatibility of 3 groups (3: 1), compatibility of 4 groups (6: 1) on the blood viscosity and whole blood reduction viscosity stronger role; compatibility 4 (6: 1) on the red cell deformation index stronger. Conclusion: Under the same total dose, the effect of hemodilution on the hemorheology indexes is obvious when the dose of leech is relatively large (3:1,6:1).