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目的了解海口地区鼻咽癌患者放射治疗的流行病学临床特征。方法选择2004年1月～2011年12月期间海口地区进行放射治疗的患者为研究对象,共计1941例。回顾分析进行放射治疗的不同年龄组、不同临床分期、不同性别和地域患者构成比情况,对照分析进行放射治疗的不同年龄组患者中断治疗和非肿瘤死亡者。结果接受治疗的人群多集中在40～59岁,所占比率高达75.4%,位居第1。该地区进行放射治疗的患者临床分期以Ⅲ期最多,占所有被调查人群的47.0%。80.0%的被调查人群生存期仅为1年。接受治疗的患者男性居多,男女所占比例的比率为2.4︰1,而区域多来自农村,农村和城镇所占比例的比率为2.3︰1。≥55岁组患者中断治疗及非肿瘤死亡者发生率显著高于﹤55岁组患者(P﹤0.05)。结论为提高放疗效果,应强化早期筛查,做到早诊断早治疗,同时应对老年患者采取个体化放疗方案,减少中断治疗和非肿瘤性死亡比例。
Objective To understand the epidemiological characteristics of radiotherapy in patients with nasopharyngeal carcinoma in Haikou area. Methods A total of 1941 patients were selected for radiation therapy in Haikou from January 2004 to December 2011. Retrospective analysis of radiotherapy in different age groups, different clinical stages, different gender and geographical composition of patients than the situation, controlled analysis of radiation treatment in different age groups discontinued treatment and non-tumor death. Results of the treatment of the population concentrated in the 40 to 59 years old, accounting for as high as 75.4%, ranked first. The patients with radiation therapy in this area had the highest stage III clinical stage, accounting for 47.0% of all surveyed population. 80.0% of the surveyed population life expectancy is only 1 year. The majority of men treated were males and females, with a ratio of 2.4: 1, while the majority of the regions were from rural areas, rural areas and urban areas with a ratio of 2.3: 1. The incidence of discontinuation and non-tumor death in patients ≥55 years old was significantly higher than that in patients <55 years old (P <0.05). Conclusion In order to improve the radiotherapy effect, early screening should be strengthened to achieve early diagnosis and early treatment, and individualized radiotherapy should be adopted in elderly patients to reduce the proportion of discontinuous treatment and non-neoplastic death.