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目的观察A型肉毒毒素治疗偏侧面肌痉挛的临床疗效。方法采用A型肉毒毒素多点局部注射治疗偏侧面肌痉挛35例。6个月后观察疗效,其中复发者1个月后再次给予治疗,最多注射治疗3次。并使用Cohen和Al-bert量表进行评估。结果6个月后显效30例,占85·7%;有效4例,占11·4%;缓解1例,占2·9%。疗效持续时间为3~6个月,复发者重复注射仍有效。治疗后出现局部肿胀3例,眼睑闭合不全2例,面肌无力、眼睑下垂各1例,但未经任何处置均在1周内恢复。结论局部注射A型肉毒毒素治疗偏侧面肌痉挛安全有效、简便易行。
Objective To observe the clinical efficacy of Botulinum toxin A in the treatment of hemifacial spasm. Methods A total of 35 cases of hemifacial spasm were treated with botulinum toxin type A injection. After 6 months, the curative effect was observed, in which relapse was given again after 1 month, and up to 3 injections were given. And evaluated using the Cohen and Al-bert scales. Results 6 months after the effective in 30 cases, accounting for 85.7%; effective in 4 cases, accounting for 11.4%; ease in 1 case, accounting for 2.9%. Duration of efficacy for 3 to 6 months, repeat relapse were still valid. After treatment, there were 3 cases of local swelling, 2 cases of eyelid insufficiency, 1 case of facial weakness and 1 case of eyelid ptosis. All cases recovered within 1 week without any treatment. Conclusion Local injection of botulinum toxin type A is safe and effective in treating hemifacial spasm.