特定的配体作用于HER 1、HER 3、HER 4等EGFR家族中的成员后 ,HER 2可以通过与这些成员形成异二聚体而激活。之后的信号转导通路主要有Ras Raf MEK MAPK通路与PI3K Akt激酶通路。产生的效应主要是使得细胞增殖加快、细胞周期加速、恶性表现增强 ,并有抗凋亡及对多种化疗药物的耐药现象。系统深入了解HER 2蛋白信号转导通路对人类认识肿瘤与发掘新的抗肿瘤药物具有重要意义 After a specific ligand acts on members of the EGFR family such as HER1, HER3, HER4, etc., HER2 can be activated by forming heterodimers with these members. Subsequent signal transduction pathways are mainly Ras Raf MEK MAPK pathway and PI3K Akt kinase pathway. The main effect is to make the cell proliferation accelerated, accelerated cell cycle, increased malignant performance, and anti-apoptosis and resistance to a variety of chemotherapy drugs. System in-depth understanding of HER 2 protein signal transduction pathway for human understanding of cancer and explore new anti-tumor drugs is of great significance