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目的探讨血清铁蛋白(SF)对宫颈癌诊断及预后判断的临床价值。方法选取梧州市红十字会医院2014年1月—2016年6月收治的宫颈良性疾病患者102例为对照组,本院同期宫颈上皮内瘤变患者105例为宫颈上皮内瘤变组,本院同期宫颈癌患者128例为宫颈癌组,采用电化学发光法检测SF表达水平,比较不同病理类型、临床分期、分化程度、肌层浸润深度、盆腔淋巴结转移、脉管浸润、肿瘤大小的宫颈癌患者SF表达水平,分析其与临床分期、分化程度、肿瘤大小的相关性。结果宫颈癌组患者SF表达水平高于宫颈上皮内瘤变组、对照组,宫颈上皮内瘤变组SF表达水平高于对照组(P<0.05)。宫颈癌组SF表达水平与临床分期、分化程度、肿瘤大小呈正相关,不同肌层浸润深度、盆腔淋巴结转移、脉管浸润的宫颈癌患者SF表达水平比较,差异无统计学意义(P>0.05)。结论 SF检测对宫颈癌的诊断和预后判断具有参考价值。
Objective To investigate the clinical value of serum ferritin (SF) in the diagnosis and prognosis of cervical cancer. Methods 102 cases of benign cervical diseases in Wuzhou Red Cross Hospital from January 2014 to June 2016 were selected as the control group. 105 cases of cervical intraepithelial neoplasia in our hospital were treated by cervical intraepithelial neoplasia group, In the same period, 128 cases of cervical cancer were cervical cancer group. The expression of SF was detected by electrochemiluminescence. The clinical pathological types, clinical stage, differentiation degree, depth of myometrial invasion, pelvic lymph node metastasis, vascular invasion and tumor size were compared Patients with SF expression levels, analysis of its clinical stage, degree of differentiation, tumor size correlation. Results The expression of SF in cervical cancer group was higher than that in cervical intraepithelial neoplasia group and control group. The expression of SF in cervical intraepithelial neoplasia group was higher than that in control group (P <0.05). The expression of SF in cervical cancer group was positively correlated with clinical stage, degree of differentiation and tumor size. There was no significant difference in SF expression between cervical cancer patients with different depth of invasion, pelvic lymph node metastasis and vascular invasion (P> 0.05) . Conclusion SF detection of cervical cancer diagnosis and prognosis of reference.