论文部分内容阅读
目的为评价ＨＢｓＡｇ作为ＨＢＶ医院感染监测指标的价值。方法以ＰＣＲ技术检测了ＨＢｓＡｇ阳性的８０例普通住院患者和１２３例肝炎患者的ＨＢＶＤＮＡ。结果普通患者的ＨＢｅＡｇ和ＨＢＶＤＮＡ阳性率显著低于肝炎患者，抗－ＨＢｅ阳性率则升高，ＨＢＶＤＮＡ阳性率的差异仅存在于抗－ＨＢｅ阳性模式之中。提示两组患者的ＨＢＶ携带率、传染性、感染阶段和感染的分子生物学机理等方面均存在差异。ＨＢｓＡｇ可作为肝炎患者预示ＨＢＶ传染性的良好指标，但对普通患者的预示作用则大为降低。结论ＨＢｓＡｇ作为ＨＢＶ医院感染监测指标的实用性仍需作进一步的研究。
Objective To evaluate the value of HBsAg as a marker of HBV infection in hospital. Methods HBVDNA was detected by PCR in 80 cases of HBsAg-positive general inpatients and 123 cases of hepatitis. Results The positive rate of HBeAg and HBVDNA in common patients was significantly lower than that in hepatitis patients, and the positive rate of anti-HBe increased. The difference of positive rate of HBVDNA only existed in anti-HBe positive mode. Prompted that the two groups of patients with HBV carrier rate, infectivity, infection stage and the molecular mechanism of infection and other differences exist. HBsAg can be used as a good predictor of HBV infection in patients with hepatitis, but the prognosis of ordinary patients is greatly reduced. Conclusion The practicality of HBsAg as a surveillance index for HBV infection still needs further study.