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目的探讨妊娠期肝内胆汁淤积症(Intrahepatic cholestasis of Pregnancy,ICP)对围产儿结局的影响及防治措施。方法回顾性分析2005～2010年ICP患者52例的临床资料,随机选取同期分娩的无ICP正常孕产妇67例(对照组)进行对比分析,比较两组围产儿结局。结果观察组胎儿窘迫、新生儿窒息、围产儿死亡及早产发生率均高于对照组,差异有统计学意义(P<0.05)。结论 ICP对围产儿结局影响极大,可引起早产、胎儿窘迫、新生儿窒息、围产儿死亡。早诊断、早治疗,加强孕产期监护,适时终止妊娠是降低其并发症的关键。
Objective To investigate the effect of intrahepatic cholestasis of pregnancy (ICP) on perinatal outcome and its prevention and treatment. Methods The clinical data of 52 patients with ICP from 2005 to 2010 were analyzed retrospectively. A total of 67 normal pregnant women without ICP at the same period were randomly selected for comparison. The perinatal outcome was compared between the two groups. Results Fetal distress, neonatal asphyxia, perinatal death and the incidence of preterm birth were higher in the observation group than in the control group, with statistical significance (P <0.05). Conclusion ICP has a great effect on perinatal outcome and can cause preterm birth, fetal distress, neonatal asphyxia and perinatal death. Early diagnosis and early treatment, to strengthen the guardianship of pregnancy, timely termination of pregnancy is the key to reducing its complications.