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目的采用meta分析系统评价乙型肝炎、丙型肝炎患者机体内血清硒水平。方法全面检索国内外公开发表的检测分析乙型、丙型肝炎患者机体内血清硒水平的文献,根据纳入和排除标准入选合格的文献,采用Rev Man 5.2软件进行meta分析。结果乙型肝炎患者的血清硒水平明显低于健康对照组(MD=-27.28μg/L,95%CI=-40.46~-14.11,P<0.01);丙型肝炎患者的血清硒水平亦明显低于健康对照组(MD=-8.10μg/L,95%CI=-13.78~-2.42,P<0.01);男性乙型肝炎患者的血清硒水平与健康对照组差异无统计学意义(MD=-54.03μg/L,95%CI=-136.69~28.64,P>0.05);女性乙型肝炎患者的血清硒水平明显低于健康对照组(MD=-12.75μg/L,95%CI=-22.06~-3.44,P<0.01);男性丙型肝炎患者的血清硒水平与健康对照组差异无统计学意义(MD=-55.31μg/L,95%CI=-158.10~47.47,P>0.05);女性丙型肝炎患者的血清硒水平明显低于健康对照组(MD=-29.75μg/L,95%CI=-51.50~-8.01,P<0.01)。结论乙型、丙型肝炎患者机体内的血清硒水平明显降低,二者具有明显的相关性。
Objective To evaluate the serum selenium level in patients with hepatitis B and C by meta-analysis system. Methods A comprehensive review of the literature published at home and abroad on the detection and analysis of serum selenium levels in patients with hepatitis B and C was conducted. Qualitative literature was selected according to inclusion and exclusion criteria, and the meta-analysis was performed using Rev Man 5.2 software. Results Serum selenium levels in patients with hepatitis B were significantly lower than those in healthy controls (MD = -27.28 μg / L, 95% CI = -40.46 ~ -14.11, P <0.01). Selenium levels in patients with hepatitis C were also significantly lower The level of serum selenium in male patients with hepatitis B was not significantly different from that in healthy controls (MD = - 8.10μg / L, 95% CI = -13.78 ~ -2.42, P <0.01) 54.03μg / L, 95% CI = -136.69 ~ 28.64, P> 0.05). Serum selenium levels in women with hepatitis B were significantly lower than those in healthy controls (MD = -12.75μg / L, 95% CI = -22.06 ~ -3.44, P <0.01). There was no significant difference in serum selenium level between male and female patients with hepatitis C (MD = -55.31μg / L, 95% CI = -158.10 ~ 47.47, P> 0.05) Serum selenium levels in patients with hepatitis C were significantly lower than those in healthy controls (MD = -29.75μg / L, 95% CI = -51.50 ~ -8.01, P <0.01). Conclusion Serum selenium levels in patients with hepatitis B and C are significantly decreased, and the two have obvious correlation.