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用薄层扫描定量法测定盐酸甜菜碱在大鼠体内的血药浓度,所得药-时数据依3P87程序进行曲线拟合,计算药物动力学参数。大鼠一次iv盐酸甜菜碱400mg/kg后,药时曲线符合开放三室模型。AUC为14599.2(μg/ml)h;大鼠一次灌胃盐酸甜菜碱400mg/kg,药时曲线符合开放一室模型,AUC为10158.8(μg/ml)h。由此可以得出盐酸甜菜碱在大鼠体内的绝对生物利用度为69.58％。
The plasma concentration of betaine hydrochloride in rats was determined by TLC-scanning quantitative method. The drug-time data were fitted by curve according to the 3P87 program to calculate pharmacokinetic parameters. After the rats were given iv hydrochloride betaine 400 mg/kg, the drug time curve was in line with the open three-compartment model. AUC was 14599.2 (μg/ml)h; Rats were given gavage with 400 mg/kg betaine hydrochloride at one time, and the drug time curve was consistent with the open one-compartment model. The AUC was 10158.8 (μg/ml)h. It can be concluded that the absolute bioavailability of betaine hydrochloride in rats is 69.58%.