目的:探讨外阴疣状癌的发病因素、临床表现、诊断及治疗。方法:回顾分析我院自1989年至今共收治3例外阴疣状癌的临床资料,并结合文献进行探讨。结果:3例疣状外阴癌均为老年,均来自经济落后、卫生条件较差的地区,且早婚、早育、多产,3例都通过2次以上活检确诊。其中2例手术治疗效果较好,术后才确诊为外阴疣状癌,1例第二次活检确诊为外阴疣状癌,放弃治疗死亡。结论:外阴疣状癌临床过程长,远处转移较少,预后较好,临床可疑病例应尽早活检,临床检查与病理结果不相符时建议活检组织要够深,防止误诊。必要时可多次活检以免漏诊。 Objective: To investigate the incidence of vulvar verrucous carcinoma, clinical manifestations, diagnosis and treatment. Methods: A retrospective analysis of our hospital from 1989 to date were treated 3 cases of genital warts cancer clinical data, combined with the literature to explore. Results: All three cases of verrucous vulvar cancer were elderly, both from economically disadvantaged areas with poor sanitary conditions. Early marriage, early childbirth and prolific fertility were confirmed in 3 cases, all of which were confirmed by more than 2 biopsies. Two cases of surgical treatment is better, was diagnosed as vulvar verrucous carcinoma after surgery, 1 case of second biopsy was diagnosed as vulvar verrucous carcinoma, to give up the treatment of death. Conclusions: The genital verrucous carcinoma has long clinical course, less distant metastasis and better prognosis. Clinical suspicious cases should be biopsy as soon as possible. When the clinical examination and pathological findings are not consistent, the biopsy should be deep enough to prevent misdiagnosis. If necessary, multiple biopsies to avoid missed diagnosis.