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醋酸棉酚和米索前列醇对体外培养大鼠黄体细胞和人蜕膜细胞都有明显的损伤作用，呈现量-效相关性。棉酚单用对黄体、蜕膜细胞的LD50分别为1．27±0．09μg／ml和3．06±0．23μg／mg；但与来索5μg／ml（在黄体细胞），10μg／ml（在人蜕膜细胞）合用时，LD50分别降至0．89±0．25μg／ml和1．88±026μg／ml；与单用棉酚相比，有显著性差异。单用米索对黄体、蜕膜细胞的LD50各为14．29±1．29μg／ml和24．37±4．49μg／ml；但与棉酚0．5μg／ml（在黄体细胞），1．0μg／ml（在蜕膜细胞）合用时，分别下降为8．79±2．18μg／ml和17.29±1．56μg／ml，与单用米索相比，均有统计学差异，显示两药合用的协同效应。
Gossypol acetate and misoprostol on rat luteal cells and human decidual cells were significantly damaged, showing a dose-response. The LD50 of gossypol on luteal and decidual cells were 1.27 ± 0.09μg / ml and 3.06 ± 0.23μg / mg, respectively. However, (In human decidual cells), the LD50 decreased to 0.89 ± 0.25μg / ml and 1.88 ± 026μg / ml, respectively; compared with the single gossypol, there was a significant difference. The LD50 of corpora luteum and decidual cells were 14.29 ± 1.29μg / ml and 24.37 ± 4.49μg / ml for moxels alone, but 0.5μg / ml for gossypol (in luteal cells), 1 .0μg / ml (in decidual cells) combined, decreased to 8.79 ± 2.18μg / ml and 17.29 ± 1.56μg / ml, respectively, compared with single misoprostol, were statistically significant, showing that two Synergistic effect of drug combination.