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RQA是一种防霉剂。本文报道了RQA的急性毒性和蓄积毒性以及采用四种体内、外短期生物试验方法进行的致突变性研究的结果。RQA的急性毒性较低,大鼠口服RQA LD_(50)为3200±188mg/kg;小鼠为1350±160mg/kg;20天的蓄积毒性试验表明RQA具中等蓄积作用。4个菌株的Ames试验、CHO细胞的SCE率、小鼠骨髓多染红细胞微核率及精子畸形率与对照比较均未见明显差异。证实RQA无效突变活性。在控制使用剂量和时间的条件下,RQA作为防霉剂使用是安全的。
RQA is a fungicide. This paper reports the acute and accumulative toxicity of RQA and the results of mutagenicity studies using four in vitro and in vivo short-term biological assays. The acute toxicity of RQA was lower. The oral RQA LD5050 was 3200 ± 188mg / kg in rats and 1350 ± 160mg / kg in mice. The accumulative toxicity test of 20 days showed that RQA had a moderate accumulative effect. Four strains of Ames test, SCE rate of CHO cells, mouse bone marrow erythrocytes micronucleus rate and sperm deformity rate compared with the control no significant difference. Confirmed RQA null mutation activity. RQA is safe to use as an antifungal agent with controlled dosages and times.