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[Objective] To select optimal formation process for Dicliptera chinensis polysaccharide granules. [Methods] Forming rate,flow,and solubility of granules were used as indicators. Single factor experiment and orthogonal experiment were carried out to optimize types and volume of auxiliary materials( filling agent and binding agent) used in granule prescription. Quality of formed granules was inspected.[Results]The optimal formation process was 1: 2. 5: 1% for Dicliptera chinensis polysaccharide: mannitol: 3% HPMC aqueous solution. The grain size,flow,and solubility of prepared granules met requirements of Chinese Pharmacopoeia. [Conclusion]The optimally selected formation process for Dicliptera chinensis polysaccharide granules is feasible and suitable for industrialized production.
[Methods] Forming rate, flow, and solubility of granules were used as indicators. Single factor experiment and orthogonal experiment were carried out to optimize types and volume of auxiliary materials (filling The optimal formation process was 1: 2.5: 1% for Dicliptera chinensis polysaccharide: mannitol: 3% HPMC aqueous solution. The grain size, flow, and solubility of prepared granules met requirements of Chinese Pharmacopoeia. [Conclusion] The optimally selected formation process for Dicliptera chinensis polysaccharide granules is feasible and suitable for industrialized production.