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为满足高强度聚焦超声(HIFU)治疗对组织损伤均匀性和高效性的需求,理论及实验研究了连续扫描模式下HIFU沿螺旋扫描路径形成的组织损伤。基于Khokhlov-Zabolotskaya-Kuznetsov方程和生物传热方程建立了声热耦合模型,数值模拟了螺旋路径栅格距离为3 mm和4 mm时不同扫描速度下HIFU辐照体模的温度场和组织损伤分布,并采用凝胶体模进行了实验验证。结果表明,采用连续螺旋模式可以使热扩散均匀化,产生分布均匀的热损伤;选择适当的栅格距离和扫描速度,发挥螺旋路径内外圈热扩散的相互影响,可以产生大范围的整体性的热损伤,同时提高治疗效率。本文工作对优化HIFU治疗效果具有指导意义。
To meet the requirement of high-intensity focused ultrasound (HIFU) treatment for tissue damage uniformity and efficiency, the tissue damage of HIFU along the helical scan path under continuous scan mode was studied theoretically and experimentally. Based on the Khokhlov-Zabolotskaya-Kuznetsov equation and the heat transfer equation, an acoustic-thermal coupling model was established to simulate the temperature field and tissue damage distribution of HIFU irradiated phantom at different scanning velocities with 3mm and 4mm helical path grids , And using gel phantom experimentally verified. The results show that the continuous spiral mode can make the thermal diffusion uniform and generate the uniform thermal damage. Selecting the appropriate grid distance and scanning velocity, the interaction between the inner and outer thermal diffusion of spiral path can be exerted to produce a large range of integral Thermal damage, while improving treatment efficiency. This work is of guiding significance in optimizing the therapeutic effect of HIFU.