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目的探讨孕中期血清铁蛋白水平(SF)与GDM的相关性及对GDM诊断的临床意义。方法对66例GDM(GDM组)患者和66名正常对照(NGT组)孕妇分析孕中期(15~20周)SF水平与孕中后期(24~28周)餐后血糖及其他一般资料,利用受试者工作特征(ROC)曲线分析SF水平对GDM的诊断价值。结果 GDM组孕中期SF水平、餐后2h平均血糖(2hPPBS)水平均高于NGT组(P均<0.001)。相关分析结果提示,孕中期SF水平与BMI、2hPPBS水平、新生儿出生体重呈正相关(r=0.388、0.401、0.455,P<0.01)。以SF水平判断孕妇发生GDM的ROC曲线下面积为0.875(95%CI:0.813~0.934)。以孕中期SF=151.87μg/L为界值判断GDM发生的敏感性、特异性和准确性分别为82.3%,93.9%,90.8%。结论孕中期高SF水平与GDM发生相关。
Objective To investigate the correlation between serum mid-term serum ferritin (SF) and GDM and its clinical significance in the diagnosis of GDM. Methods 66 postmenopausal women with GDM (GDM group) and 66 healthy controls (NGT group) were enrolled in this study. SF levels during the second trimester (15 to 20 weeks) and postprandial blood glucose and other general information during the second trimester (24 to 28 weeks) The receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of SF level in GDM. Results The level of SF in the second trimester of GDM group was significantly higher than that in NGT group (P <0.001). Correlation analysis indicated that the level of SF in the second trimester was positively correlated with the level of BMI, 2hPPBS and the birth weight of newborns (r = 0.388,0.401,0.455, P <0.01). The area under the ROC curve for determining GDM in pregnant women at the SF level was 0.875 (95% CI: 0.813-0.934). The sensitivity, specificity and accuracy of determining the occurrence of GDM by the second trimester SF = 151.87μg / L were 82.3%, 93.9% and 90.8%, respectively. Conclusion The high-SF level in the second trimester is related to the occurrence of GDM.