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用日本血吸虫虫卵肉芽肿的小鼠肺模型进行研究。ＩＣＲ雄性小鼠３２只，分成免疫组和佐剂对照组各１６只，免疫组小鼠经ｒＳｊｃ２６ＧＳＴ免疫。免疫结束后第５天两组小鼠均由尾静脉注射新鲜日本血吸虫虫卵悬液０．２ｍｌ（内含活卵１５００－２０００个），于注卵后第８天、１６天和２１天分批剖杀小鼠，观察肺部形成的虫卵肉芽肿病变。结果发现免疫鼠肺内肉芽肿大小受到明显抑制，免疫后第８天、１６天、２１天肺肉芽肿平均直径分别为１００．００±１２．６μｍ，１０６．４３±１１．４μｍ，１０５．７０±１１．８μｍ，对照鼠在相应时间分别为１４１．９０±２３．４μｍ，１７６．６７±３４．９μｍ，１９９．５３±２１．７μｍ，抑制率从８天的２９．５％、１６天的３９．８％到２１天的４７．０％逐渐增加，并且免疫组肺相对湿重也较佐剂对照组有所减少，证实ｒＳｊｃ２６ＧＳＴ具有明确的抗肉芽肿病变效应。
Study on mouse lung model of Schistosoma japonicum egg granuloma. Thirty-two ICR male mice were divided into 16 immunized and 16 adjuvant-treated groups, respectively. Immunized mice were immunized with rSjc26GST. On the 5th day after the immunization, both groups of mice were injected 0.2ml of fresh Schistosoma japonicum egg suspension (containing 1500-2000 live eggs) from the tail vein on day 8, day 16 and day 21 after injection Mice were killed in batches to observe the formation of the egg granuloma lesions in the lungs. The results showed that the granuloma size was significantly inhibited in the immunized mice. The average diameters of pulmonary granulomas on the 8th, 16th and 21st days after immunization were 100.00 ± 12.6μm, 106.43 ± 11.4μm and 105.70 ± 11.8μm, respectively. The control rats were 141.90 ± 23.4μm, 176.67 ± 34.9μm and 199.53 ± 21.7μm respectively at the corresponding time, with the inhibition rates from 29.5% at 8 days and 16 days From 39.8% to 47.0% of 21 days, the relative lung wet weight of the immunized group was also decreased compared with the adjuvant control group, demonstrating that rSjc26GST has a clear anti-granulomatous lesion effect.