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作者为探讨沙眼发病机理,以E型沙眼衣原体BOUR株(自非流行地区沙眼分离者)接种恒河猴4只及Cynomolgus猴4只。接种前所有猴眼皆属正常。第一次都接种双眼,每眼滴人20μl50%ELD_(50)衣原体悬液。此后每隔1周右眼再滴人同量同样衣原体悬液一次。实验结果:Cynomolgus猴组:第一次接种1周后,所有猴眼皆发生急性滤泡性结膜炎;3-5周后有的于角膜缘及球结膜发生滤泡。重复接种虽只限于右眼,但双眼发生症状均相似,病程亦无何差异。初次感染3-6周后3只猴睑结膜发生线状瘢痕,7周时1猴发生交织网状瘢痕,待21周时4猴的双眼皆发生典型的沙眼瘢痕。54周时瘢痕仍在发展,但未发生睑内翻及倒睫。
In order to investigate the pathogenesis of trachoma, 4 Chlamydia trachomatis and 4 Cynomolgus monkeys were vaccinated with Chlamydia trachomatis type BOUR (isolated from trachoma in non-endemic areas). All monkey eyes are normal before inoculation. For the first time, both eyes were inoculated with 20 μl of 50% ELD_ (50) Chlamydia suspension in each eye. After every other week since the right eye and then drip the same amount of the same chlamydial suspension once. Experimental results: Cynomolgus monkey group: All follicular conjunctivitis occurred in all monkey eyes after one week of the first vaccination. Follicles occurred on the limbus and conjunctiva 3-5 weeks later. Although repeated vaccination is limited to the right eye, but the symptoms of both eyes are similar, no difference in course of disease. After 3 to 6 weeks of initial infection, three monkey conjunctiva had a linear scar. At week 7, 1 monkey had an interlacing scar. At 21 weeks, all 4 monkeys had typical trachoma scarring in both eyes. At 54 weeks, the scar was still developing, but no ectropion or trichiasis occurred.