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Kostial曾报道初生大鼠胃肠道对氯化汞的吸收率高于成年大鼠,而胃肠道吸收汞的程度又决定了体内汞的蓄积。所以,本文作者研究了初生大鼠和成年大鼠胃肠道吸收汞与鼠龄的相互关系以及汞在肠道的转运。实验用Sprague-Dawley初生大鼠和成年大鼠,采用Walsh′s整体肠分段实验法,选用十二指肠和回肠进行实验。初生大鼠(6、13、23天)和成年大鼠(7周)实验肠段长度分别为4、7和10 cm。将~(203)Hg标记的氯化汞或氯化甲基汞溶液注入实验肠段(每kg体重相同剂量)。按选定的时间处死初生大鼠和成年大鼠。切取
Kostial reported that the absorptive rate of mercuric chloride in the gastrointestinal tract of newborn rats was higher than that of adult rats, and the degree of mercury absorption in the gastrointestinal tract in turn determines the accumulation of mercury in the body. Therefore, the authors studied the relationship between mercury uptake in the gastrointestinal tract of newborn rats and adult rats and their age and mercury transport in the intestine. Experimental Sprague-Dawley rats and adult rats, using Walsh’s overall intestine segment method, the choice of duodenum and ileum experiments. The lengths of experimental intestine in neonatal rats (6, 13, and 23 days) and in adult rats (7 weeks) were 4, 7 and 10 cm, respectively. The ~ (203) Hg-labeled mercuric chloride or methylmercuric chloride solution was injected into the experimental intestine (same dose per kg body weight). Neonatal and adult rats were sacrificed at selected times. Cut