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目的 :研究 3 磷酸甘油醛脱氢酶的修饰蛋白 (modifierprotein ,MP)对急性肾功能衰竭 (acuterenalfail ure ,ARF)大鼠丙二醛 (malondialdehyde ,MDA)和超氧化物歧化酶 (superoxidedismutase,SOD)的影响。 方法 :利用庆大霉素致ARF的动物模型 ,将大鼠随机分成 4组 :正常对照组、阴性对照组、阳性对照组和实验组 ,采用硫代巴比妥酸法和羟胺法分别测定血清及肾皮质匀浆MDA和SOD ,光镜、电镜观察肾组织学改变 ,同时测定血肌酐(Scr)。结果 :实验组、阳性对照组血清及肾皮质匀浆MDA明显下降 ,SOD明显上升 ,P <0 .0 1。同时Scr下降。光镜、电镜示实验组、阳性对照组肾脏病理仅呈灶状改变。比阴性对照组减轻。结论 :MP可以缓解氧自由基损伤 ,减轻ARF时的肾脏病理改变 ,改善肾功能
Objective: To investigate the effect of modifier protein MP (3) on malondialdehyde (MDA) and superoxide dismutase (SOD) in rats with acute renal failure (ARF) Impact. Methods: The animal model of gentamicin-induced ARF was used. The rats were randomly divided into 4 groups: normal control group, negative control group, positive control group and experimental group. Serum was determined by thiobarbituric acid method and hydroxylamine method And renal cortical homogenate MDA and SOD, light microscopy, electron microscopy renal histological changes, and determination of serum creatinine (Scr). Results: In the experimental group and the positive control group, serum MDA and renal cortical homogenate MDA decreased significantly, while SOD increased significantly (P <0.01). At the same time Scr decreased. Light microscope, electron microscope showed that the experimental group and the positive control group showed only focal changes in renal pathology. Less than the negative control group. Conclusion: MP can relieve oxygen free radical injury, reduce renal pathological changes when ARF, improve renal function