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应用双抗体夹心ELISA法、3H-TdR掺入法和125I-UdR释放法对24例鼻咽癌(NPC)患者YAG激光汽化结合光动力学治疗前后外周血可溶性IL-2受体(SIL-2R)、白细胞介素2(IL-2)水平和自然杀伤细胞(NK)活性分别进行测定。结果表明鼻咽癌患者在接受激光光动力学治疗后SIL-2R水平呈明显下降(P<0.0005),而IL-2水平和NK活性显著上升(P<0.0005)。结果提示激光光动力学治疗对恢复鼻咽癌患者免疫功能起促进作用。
Twenty-four patients with nasopharyngeal carcinoma (NPC) were treated with YAG laser vaporization combined with peripheral blood soluble IL-2 receptor (SIL-2R) before and after photodynamic therapy with double antibody sandwich ELISA, 3H-TdR incorporation and 125I- ), Interleukin 2 (IL-2) and natural killer (NK) activity were measured. The results showed that SIL-2R level was significantly decreased in patients with nasopharyngeal carcinoma after laser photodynamic therapy (P <0.0005), while IL-2 level and NK activity were significantly increased (P <0.0005). The results suggest that laser photodynamic therapy can promote the recovery of immune function in patients with nasopharyngeal carcinoma.