Creutzfeldt-Jakob 氏病一般又称为亚急性脑海绵状变性。自1920年 Creutzfeldt 及1921年Jakob 报道以后又陆续有过报道。此病颇为罕见,临床诊断困难,最终往往死亡。在1955年以后开始有少数患者在生前经脑组织活检作出诊断。1968年 Gibbs 等发现用患者的脑组织混悬液接种于黑猩猩可使之出现相似的临床及病理表现。此后有不少证据提示此病是由 Creutzfeldt-Jakob’s disease is also commonly referred to as subacute cavernous degeneration. Since 1920, Creutzfeldt and Jakob reported in 1921 after another have been reported. The disease is rather rare, difficult to diagnose clinically, and eventually often dies. A small number of patients started their diagnosis by brain biopsies after 1955. In 1968, Gibbs et al found that inoculation of chimpanzees with a patient’s brain tissue suspension resulted in similar clinical and pathological findings. Since then there is a lot of evidence that the disease is caused by