1949年 Li 及1955年 Rigas 等先后从植物菜豆种子中提取了一种能凝集红细胞的物质,称为植物血球凝集素,(Phytohemagglutinin,简称 PHA)。1963年 Aub 首先指出肿瘤细胞与正常细胞相比,更易被植物凝集素所凝集。以后研究证明 PHA 对癌细胞的凝集力为正常细胞的12倍。现已知道 PHA 在体外能增加淋巴细胞的细胞毒作用,从而能破坏肿瘤细胞及其它某些靶细胞;PHA 在体内可以延长肿瘤小鼠的生存期,抑制肿瘤的生长。临 Li in 1949 and Rigas in 1955 had successively extracted a substance capable of agglutinating red blood cells from plant bean seeds, called Phytohemagglutinin (PHA). 1963 Aub first pointed out that tumor cells are more likely to be agglutinated by lectins than normal cells. Future studies have shown that PHA’s cohesion to cancer cells is 12 times that of normal cells. It is known that PHA can increase the cytotoxic effect of lymphocytes in vitro, and thus can destroy tumor cells and certain other target cells; PHA can prolong the survival period of tumor mice and inhibit the growth of tumors in vivo. Pro