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目的:对比甲钴胺注射液、血栓通联合安诺治疗仪治疗糖尿病周围神经病变的临床观察。方法:2014年6月—2015年6月收治的90例糖尿病周围神经病变患者,按照数字表法随机分为试验组和对照组,每组45例。对照组患者进行甲钴胺注射液静脉滴注+安诺治疗仪配合治疗,试验组在对照组基础上联合血栓通配合治疗。对比两组患者治疗总有效率、运动神经传导速度(MNCV)及感觉神经传导速度(SNCV)及不良反应发生率。结果:试验组患者治疗总有效率(97.78%)高于对照组(84.45%),但差异在统计学上无意义(P>0.05);但试验组患者周围神经传导速度(60.27±3.93)m/s、(54.98±5.24)m/s、(55.67±5.14)m/s、(61.73±3.21)m/s明显高于对照组(50.28±4.23)m/s、(44.11±4.19)m/s、(42.57±5.46)m/s、(43.38±6.17)m/s,其差异在统计学上有意义(P<0.05);试验组患者经治疗后的不良反应发生率(6.67%)对照组(8.89%)较相近,其差异在统计学上无意义(P>0.05)。结论:应用甲钴胺注射液、血栓通联合安诺治疗仪对糖尿病周围神经病变患者进行治疗,不良反应发生率无明显差异,其临床总有效率及患者周围神经传导速度均有提高,具有较好的短期临床效果,但远期的临床效果还需要通过长期随访和加大样本量来进一步证实。
Objective: To compare the clinical observation of mecobalamin injection and Xueshuantong combined with Anno therapeutic apparatus for the treatment of diabetic peripheral neuropathy. Methods: Ninety patients with diabetic peripheral neuropathy who were admitted to our hospital from June 2014 to June 2015 were randomly divided into experimental group and control group according to the digital meter method, with 45 cases in each group. Patients in the control group were treated with intravenous infusion of Mecobalamin and Anorinotherapy. The experimental group was treated with Xueshuantong combined with the control group. The total effective rate of treatment, motor nerve conduction velocity (MNCV) and sensory nerve conduction velocity (SNCV) and incidence of adverse reactions were compared between the two groups. Results: The total effective rate (97.78%) in the experimental group was significantly higher than that in the control group (84.45%), but the difference was statistically insignificant (P> 0.05). However, the peripheral nerve conduction velocity in the experimental group was (60.27 ± 3.93) m (54.98 ± 5.24) m / s, (55.67 ± 5.14) m / s, (61.73 ± 3.21) m / s and 50.48 ± 4.23 m / s in the control group, s, (42.57 ± 5.46) m / s and (43.38 ± 6.17) m / s respectively, the difference was statistically significant (P <0.05). The incidence of adverse reactions in the trial group was 6.67% (8.89%) were similar, the difference was statistically insignificant (P> 0.05). Conclusion: Mecobalamin injection and thrombus combined with Annuo therapeutic apparatus for the treatment of diabetic peripheral neuropathy patients with no significant difference in the incidence of adverse reactions, the total effective rate of the clinical and peripheral nerve conduction velocity of patients have increased, with more Good short-term clinical results, but the long-term clinical results also need to be further confirmed by long-term follow-up and increase the sample size.