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目的探讨婴幼儿喘息性疾病患者的痰液EC、IL-5、ECP水平,达到早期诊断及早期干预。方法选择2008～2010年收治的1个月至3岁的毛细支气管炎(毛支)、喘息性肺炎(喘肺)112例,分为二组,其中第一次发作毛支、喘肺组84例,发作≥2次组28例,支气管肺炎(无喘息症状)28例为第三组。吸取痰夜1ml进行嗜酸性粒细胞计数(EC),IL-5、ECP检测。结果反复喘息组痰夜EC,IL-5、ECP明显高于其他二组,差异有统计学意义,第一次发作毛支、喘肺组与支气管肺炎组之间差异则无统计学意义;EC、IL-5、ECP之间存在显著正相关;EC、IL-5、ECP水平在同时存在喘息和特应性的患儿最高,在既没有喘息也无个人特应性的患儿最低。结论诱导痰细胞组份EC、IL-5、ECP检测操作简单、无创,且能可靠地预测婴幼儿喘息性疾病的转归,可以在临床上进一步推广使用。
Objective To investigate the levels of sputum EC, IL-5 and ECP in asthmatic children with infantile asthma and achieve early diagnosis and early intervention. Methods A total of 112 patients with bronchiolitis (bronchiolitis) and asthmatic pneumonia (asthmatic lung) from 1 month to 3 years old who were admitted from 2008 to 2010 were divided into two groups. The first episode of hair bronchitis and asthma group 84 Cases, episodes ≥ 2 times in 28 cases, bronchial pneumonia (no wheezing symptoms) 28 cases for the third group. Suction sputum night 1ml eosinophil count (EC), IL-5, ECP test. Results The serum levels of EC, IL-5 and ECP in patients with repeated wheezing were significantly higher than those in the other two groups, the difference was statistically significant. There was no significant difference between the first episode of bronchiolitis, bronchopneumonia and bronchopneumonia. EC , IL-5 and ECP. EC, IL-5 and ECP levels were the highest in both wheezing and atopic children, and the lowest in those with neither wheezing nor personal predilection. Conclusion The EC, IL-5 and ECP of induced sputum cells are simple, noninvasive, and can reliably predict the outcome of asthmatic wheezing in infants and young children. It can be further popularized in clinic.