前阿黑皮素原基因(POMc)已被证明是研究神经多肽生物合成,合成后处理以及分泌的一个很有价值的模型。POMC生物合成的调节主要发生在转录水平,其它的神经多肽基因系统一般也是如此。然而,比较难以理解的是外来刺激最终导致POMC基因转录效率改变的传导途径。因为大多数 Pro-pro-opiomelanocortin (POMc) has been shown to be a valuable model for studying neuropeptide biosynthesis, post-synthesis processing, and secretion. The regulation of POMC biosynthesis occurs mainly at the transcriptional level, as is the generality of other neuropeptide gene systems. However, what is more difficult to understand is that the extrinsic stimuli ultimately lead to a pathway that changes the transcriptional efficiency of the POMC gene. Because most