由白色念珠菌和其他机会真菌引起深部感染的机率在增加,但仍缺乏有效的药物。以咪唑类和三唑类为代表的合成抗真茵药物,主要是抑制麦角固醇的14α-去甲基作用的生物合成。为了筛选天然产生的类似的抑制剂,作者设计了以菌株的羊毛甾醇14α-去甲基酶含量为指标的筛选方法,分离到Pycn-idiophora dipersa。该菌株有如下的特征:(1)有性子实体是一个具有分开包皮的真正闭囊壳;(2)子囊有一个单层壁;(3)子囊孢子是旅离的,数量高达每个子囊32个; The chances of deep infections caused by Candida albicans and other opportunistic fungi are on the rise, but there is a lack of effective medicine. Synthetic antifungal agents represented by imidazoles and triazoles are mainly those which inhibit the 14α-demethyl function of ergosterol. In order to screen for naturally occurring similar inhibitors, the authors designed a screening method based on the level of lanosterol 14α-demethylase in the strain, and isolated Pycn-idiophora dipersa. The strain has the following characteristics: (1) the sexual entity is a true closed shell with a separate foreskin; (2) the ascus has a single wall; (3) the ascospores are exiting as many as as many as 30 One