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目的探讨表皮生长因子受体2(HER-2)在胃腺癌组织中的表达及其与胃癌各临床病理特征的关系。方法应用免疫组织化学(PV-9000)方法检测90例胃癌组织中的HER-2蛋白的表达,并对HER-2的蛋白不同表达水平与胃腺癌各临床病理学特征进行分析。结果胃腺癌组织中HER-2蛋白阳性表达率为14.4%(13/90);HER-2蛋白表达与患者的性别无关;年龄≥65岁者阳性表达率(23.8%)高于年龄<65岁者(6.3%);低分化腺癌组阳性表达率(27.3%)高于高中分化腺癌(8.2%);Ⅲ、Ⅳ期(22.2%)阳性表达率高于I、Ⅱ期(2.8%),有区域淋巴结转移的阳性表达率(21.7%)高于无区域淋巴结转移者(6.8%),肿瘤直径≥5cm的阳性表达率(23.7%)高于肿瘤直径<5cm(7.7%),以上各组之间差异均有统计学意义(均P<0.05)。结论 HER-2蛋白表达与年龄、分化程度、分期、肿瘤大小及区域淋巴结有相关性,提示HER-2在胃癌的发生发展中可能起重要作用。
Objective To investigate the expression of epidermal growth factor receptor 2 (HER-2) in gastric adenocarcinoma and its relationship with the clinicopathological characteristics of gastric cancer. Methods Immunohistochemistry (PV-9000) was used to detect the expression of HER-2 protein in 90 cases of gastric carcinoma. The expression of HER-2 in different tissues and clinicopathological characteristics of gastric adenocarcinoma were analyzed. Results The positive rate of HER-2 protein expression in gastric adenocarcinoma was 14.4% (13/90). The expression of HER-2 protein was not related to the gender of the patients. The positive rate of HER-2 protein expression was 23.8% (7.3%). The positive expression rate in poorly differentiated adenocarcinoma group (27.3%) was higher than that in high differentiated adenocarcinoma (8.2%). The positive rates in stage Ⅲ and Ⅳ (22.2% (21.7%) were higher than those without regional lymph node metastasis (6.8%). The positive rate of tumor with diameter> = 5cm (23.7%) was higher than that with tumor diameter <5cm (7.7%). Differences between the two groups were statistically significant (P <0.05). Conclusion The correlation between the expression of HER-2 protein and age, differentiation degree, stage, tumor size and regional lymph nodes suggest that HER-2 may play an important role in the development of gastric cancer.